Dr Foo Jhi Biau




Dr Foo Jhi Biau

Lecturer I 

PhD in Pharmacology and Toxicology (Universiti Putra Malaysia)
MSc in Oncology (Universiti Putra Malaysia)
BSc Biomedical Sciences (Universiti Putra Malaysia)

jhibiau.foo@taylors.edu.my
Expertise
  • Drug discovery and development
  • Pharmacology and therapeutics

Research Interests
  • Elucidation of signalling pathways of anticancer compounds (natural/synthetic compounds) by using cell-line and animal models.
  • Targeted therapy using Nano-technology.
  • Explore stem cell for the treatment of diseases.

Research Grants Awarded
  • Investigating the role of anti-inflammatory property of Andrographolide and its semi-synthetic derivatives in the treatment of psoriasis: In vitro study. MAHSA University Research Grant (RM 50,000). Co-investigator (2017-2018).
  • Investigating the anti-cancer properties of copper complex towards breast cancer: In vitro studies. MAHSA University Research Grant (RM 40,000). Principal Investigator (2016-2017).
  • Cytotoxic properties of Dillenia suffruticosa dichloromethane extract towards breast cancer cells. Universiti Putra Malaysia Research University Grant Scheme (RUGS) (RM 15,000). Co-investigator (2012-2014).

Publication

Peer Reviewed Papers
  • Beh, C.Y., How, C.W., Foo, J.B., Foong, J.N., Selvarajah, G.T. and Rasedee, A. 2017. Development of erythropoietin receptor-targeted drug delivery system against breast cancer using tamoxifen-loaded nanostructured lipid carriers. Drug Design, Development and Therapy 2017 (11): 771-782, IF=2.88, Q2.
  • Ong, Y.S., Saiful Yazan, L., Ng, W.K., Noordin, M.M., Sapuan, S., Foo, J.B. and Tor, Y.S. 2016. Acute and subacute toxicity profiles of thymoquinone-loaded nanostructured lipid carrier in BALB/c mice. International Journal of Nanomedicine 11: 5905-5915, IF=4.32, Q1.
  • Napsiah, A.R. Latifah, S.Y., Wibowo, A., Ahmat, N., Foo, J.B., Tor, Y.S., Yeap, S.K., Razali, Z.A., Ong, Y.S. and Fakurazi, S. 2016. Induction of apoptosis and G2/M arrest by ampelopsin E from Dryobalanops towards triple negative breast cancer cells, MDA-MB-231. BMC Complementary and Alternative Medicine 16: Article 354, 11 pages, IF=1.987, Q1.
  • Foo, J.B., Latifah, S.Y., Tor, Y.S., Wibowo, A., Ismail, N., Armania, Cheah, Y.K. and Abdullah, R. 2016. Dillenia suffruticosa dichloromethane root extract induced apoptosis towards MDA-MB-231 triple-negative breast cancer cells. Journal of Ethnopharmacology 187: 195-204, IF=2.939, Q1.
  • Yazan, L.S., Abd Rahman, N., Chan, K.W., Wan Nor Hafiza, W.A., Tor, Y.S. and Foo, J.B. 2016. Phenolics-saponins rich fraction of defatted kenaf seed meal exhibits cytotoxicity towards cancer cell lines. Asian Pacific Journal of Tropical Biomedicine 6(5):930-934, Citation-indexed.
  • Wan Nor Hafiza, W.A., Yazan, L.S., Tor, Y.S., Foo, J.B., Armania, N. and Rahman, H.S. 2016. Endoplasmic reticulum stress-induced apoptotic pathway and mitochondrial dysregulation in HeLa cells treated with dichloromethane extract of Dillenia suffruticosa. Pharmacognosy Magazine 12(45): 86-95, IF=1.256, Q3.
  • Latifah, S.Y., Ong, Y.S., Zaaba, N.E., Mohd Ali, Razana, Foo, J.B. and Tor, Y.S. 2015. Anti-breast cancer properties and toxicity of Dillenia suffruticosa root aqueous extract in BALB/c mice. Asian Pacific Journal of Tropical Biomedicine 5(12): 1018-1026, Citation-indexed.
  • Tor, Y.S., Latifah, S.Y., Foo, J.B., Wibowo, A., Ismail, N., Armania, Cheah, Y.K., Abdullah, R., Ismail, M., Ismail, I.S. and Yeap, S.K. 2015. Induction of apoptosis in MCF-7 cells via oxidative stress generation, mitochondria-dependent and caspase-independent pathway by ethyl acetate extract of Dillenia suffruticosa and its chemical profile. PLoS One 10(6): e0127441, IF=3.23, Q2.
  • Foo, J.B., Latifah, S.Y., Tor, Y.S., Wibowo, A., Ismail, N., How, C.W., Armania, N., Loh, S.P., Ismail, I.S., Cheah, Y.K. and Abdullah, R. 2015. Induction of cell cycle arrest and apoptosis by betulinic acid-rich fraction from Dillenia suffruticosa root in MCF-7 cells involved p53/p21 and mitochondrial signalling pathway. Journal of Ethnopharmacology 166: 270-278, IF=2.939, Q1.
  • Tan, J.M., Foo, J.B., Fakurazi, S. and Hussein, M.Z. 2015. Release behaviour and toxicity evaluation of levodopa from carboxylated single-walled carbon nanotubes. Beilstein Journal of Nanotechnology 6: 243-253, IF=2.332, Q1.
  • Ismail, N., Ismail, M., Imam, M.U., Fathy, S.F., Azmi, N.H. and Foo, J.B. 2014. Mechanistic basis for protection of differentiated SH-SY5Y cells by oryzanol-rich fraction against hydrogen peroxide-induced neurotoxicity. BMC Complementary and Alternative Medicine 14: Article 467, 11 pages, IF=1.877, Q2.
  • Foo, J.B., Latifah, S.Y., Tor, Y.S., Armania, N., Ismail, N., Imam, M.U., Yeap, S.K., Cheah, Y.K., Abdullah, R. and Ismail, M. 2014. Induction of cell cycle arrest and apoptosis in caspase-3 deficient MCF-7 cells by Dillenia suffruticosa root extract via multiple signalling pathways. BMC Complementary and Alternative Medicine 14: Article 197, 16 pages, IF=1.877, Q2.
  • Tor, Y.S., Latifah, S.Y., Foo, J.B., Armania, N., Cheah, Y.K., Abdullah, R., Imam, M.U., Ismail, N. and Ismail, M. 2014. Induction of apoptosis through oxidative stress-related pathways in MCF-7, human breast cancer cells, by ethyl acetate extract of Dillenia suffruticosa. BMC Complementary and Alternative Medicine 14: Article 55, 12 pages, IF=1.877, Q2.
  • Armania, N., Latifah, S.Y., Ismail, I.S., Foo, J.B., Tor, Y.S., Ishak, N., Ismail, N. and Ismail, M. 2013. Dillenia suffruticosa extract inhibits proliferation of human breast cancer cell lines (MCF-7 and MDA-MB- 231) via induction of G2/M arrest and apoptosis. Molecules 18: 13320-13339, IF=2.095, Q3.
  • Armania, N., Latifah, S.Y., Musa, S.N., Ismail, I.S., Foo, J.B., Chan, K.W., Noreen, H., Hisyam, A.H., Zulfahmi, S., Ismail, M. 2013. Dillenia suffruticosa exhibited antioxidant and cytotoxic activity through induction of apoptosis and G2/M cell cycle arrest. Journal of Ethnopharmacology 146: 525-535, IF=2.939, Q1.
  • Ismail, N., Ismail, M., Fathy, S.F., Musa, S.N.A., Imam, M.U., Foo, J.B., Iqbal, S. 2012. Neuroprotective effects of germinated brown rice against hydrogen peroxide induced cell death in human SH-SY5Y cells. International Journal of Molecular Sciences 13: 9692-9708, IF=2.339, Q2.
  • Foo, J.B., Latifah, S.Y., Mansor, S.M., Ismail, N., Tahir, P.M. and Ismail, M. 2012. Kenaf seed oil from supercritical carbon dioxide fluid extraction inhibits the proliferation of WEHI-3B leukaemia cells in vivo. Journal of Medicinal Plants Research 6: 1429-1436, Citation-indexed.
  • Latifah, S.Y., Foo, J.B., Ghafar, S. A. A., Chan, K. W., Tahir, P. M. and Ismail, M. 2011. Effect of kenaf seed oil from different ways of extraction towards ovarian cancer cells. Food and Bioproducts Processing 89: 328-332, IF=2.285, Q1.
  • Foo, J.B., Latifah, S.Y., Chan, K.W., Tahir, P.M. and Ismail, M. 2011. Kenaf seed oil from supercritical carbon dioxide fluid extraction induced G1 phase cell cycle arrest and apoptosis in leukaemia cells. African Journal of Biotechnology 10: 5389-5397, Citation-indexed.
  • Latifah, S.Y., Foo, J.B., Chan, K.W., Tahir, P.M. and Ismail, M. 2011. Kenaf seed oil from supercritical carbon dioxide fluid extraction shows cytotoxic effects towards various cancer cell lines. African Journal of Biotechnology 10: 5381-5388, Citation-indexed.

Conference Abstracts / Proceedings
  • Foo, J.B., Lim, J.H., Lor, Y.Z., Low, M.L., Zainol, R., Eh-Dam, V., How, C.W., Latifah, S.Y. Copper compex induced cell cycle arrest and apoptosis towards MDA-MB-231 breast cancer cells. The 2nd Malaysia Zebrafish Disease Model Workshop 2017 (2-4 Oct 2017). Brain Research Institute Monash Sunway (BRIMS), Monash University, Malaysia (poster presentation).
  • Foo, J.B., Lim, J.H., Lor, Y.Z., Low, M.L., Zainol, R., Eh-Dam, V., How, C.W., Latifah, S.Y. Copper compex induced cell cycle arrest and apoptosis towards MDA-MB-231 breast cancer cells. 5th International Postgraduate Conference on Pharmaceutical Sciences 2017 (17-18 May 2017). Faculty of Pharmacy, Universiti Teknologi MARA Puncak Alam, Malaysia (Abstract page 111, oral presentation).
  • Foo, J.B., Latifah, S.Y., Tor, Y.S., Armania, N., Ismail, N., How, C.W., Wibowo, A., Cheah, Y.K. and Abdullah, R. The MAHSA Inaugural Research Conference Cancer: Emperor of All Meladies (4th Oct 2015). Auditorium, Jalan University Campus (JUC), MAHSA University, Kuala Lumpur (Abstract page 29, oral presentation).
  • Foo, J.B., Latifah, S.Y., Tor, Y.S., Armania, N., Ismail, N., Imam, M.U., Yeap, S.K., Cheah, Y.K., Abdullah, R. and Ismail, M. 2014. Induction of cell cycle arrest and apoptosis in caspase-3 deficient MCF-7 cells by Dillenia suffruticosa root extract via multiple signalling pathways. The 5th International Conference on Natural Products for Health and Beauty (NATPRO) (6th-8th May 2014). Moevenpick Resort & Spa Karon Beach Phuket, Phuket, Thailand (Abstract page 221, poster presentation).
  • Tor, Y.S., Latifah, S.Y., Foo, J.B., Armania, N., Ismail, N., Imam, M.U., Yeap, S.K., Cheah, Y.K., Abdullah, R. and Ismail, M. Induction of apoptosis through oxidative stress related pathways in MCF-7, human breast cancer cells, by ethyl acetate extract of Dillenia suffruticosa. The 5th International Conference on Natural Products for Health and Beauty (NATPRO5) (6th-8th May 2014). Moevenpick Resort & Spa Karon Beach Phuket, Phuket, Thailand (Abstract page 212, poster presentation).
  • Wan Abd Ghani, W.N.H., Latifah, S.Y., Foo, J.B., Tor, Y.S., Armania, N. and Rahman, H.S. Dillenia suffruticosa extracts inhibits proliferation of cervival cancer cells via G2/M arrest and apoptosis through mitochondrial dysregulation and endoplasmic reticulum stress-induced apoptosis. The 5th International Conference on Natural Products for Health and Beauty (NATPRO5) (6th-8th May 2014). Moevenpick Resort & Spa Karon Beach Phuket, Phuket, Thailand (Abstract page 260, poster presentation).
  • Armania, N., Latifah, S.Y., Foo, J.B., Ismail, I.S. and Ismail, M. Induction of apoptosis and G2/M arrest in human breast cancer cell lines by active fraction of Dillenia suffructicosa extract. The Fourth International Conference on Natural Products for Health and Beauty (NATPRO4) (28th -30th November, 2012). Chiang Mai Orchid Hotel, Chiang Mai, Thailand (Abstract page 364, poster presentation).
  • Armania, N., Latifah, S.Y., Ismail, I.S., Foo, J.B., Husain, N. and Ismail, M. Dillenia suffruticosa extracts exhibited higher antioxidant and cytotoxic properties through induction of apoptosis. International Seminar on Natural Products Medicines (ISNPM 2012) (22th -23th November). West and Eat Hall of Bandung, Institute of Technology, Bandung, Indonesia (Abstract page 33-34, poster presentation).
  • Latifah, S.Y., Foo, J.B., Tahir, P.M. and Ismail, M. 2010. Kenaf seed supercritical fluid oil inhibits the proliferation of WEHI-3B leukaemia cells in vivo. The Kenaf Colloquium 2010 (30th November -2nd December 2010). The Pullman Hotel, Putrajaya, Malaysia (poster presentation).
  • Latifah, S.Y., Foo, J.B., Wei, C.K. and Ismail, M. 2009. Kenaf seed oil from supercritical carbon dioxide fluid extraction was cytotoxic towards human breast cancer (MDA-MB-231) and leukemic (MOLT-4) cell lines. The International Conference on Kenaf and Allied Fibres 2009 (ICKAF 2009) (1st -3rd December 2009). The Legend Hotel, Kuala Lumpur, Malaysia (Abstract page 29, oral presentation).
  • Latifah, S.Y., Foo, J.B., Ghafar, S.A.A. and Ismail, M. 2008. Oil of kenaf seed kills ovarian cancer cells in a dose-dependent manner. The National Seminar of Oil and Fats 2008 (18th-19th November 2008). Hyatt Regency Resort, Kuantan, Malaysia (Abstract page 61, poster presentation). 

Scholarly Activities / Industry Experience
  • Lecturer, Faculty of Pharmacy, MAHSA University (May 2015-Nov 2017).
  • Head of Department, Department of Pharmacology, Faculty of Pharmacy, MAHSA University (August 2016-October 2017).
  • Final Year Project Coordinator, Bachelor of Pharmacy, Faculty of Pharmacy, MAHSA University (February 2016-Oct 2017).
  • EQUAL member, Faculty of Pharmacy, MAHSA University (To check programme files before MQA visit).
  • Internal Auditor, MAHSA University (To audit assessment files from other Faculties before MQA visit).
  • Research Trainee. Research attachment at Faculty of Medicine & Health Sciences, University of Nottingham, United Kingdom (UK) under the supervision of Assoc. Prof. Dr. Cinzia Allegrucci (lecturer and researcher in Molecular Genetics and Cell Biology). Experience epigenetic analysis (Reprograming of cancer stem cell).
  • Organiser and Facilitator, Animal Cell Culture Workshop (2010-2014), Organised by Institute of Bioscience, Universiti Putra Malaysia.
  • Facilitator, Flow cytometry workshop 2011, organised by Institute of Bioscience, Universiti Putra Malaysia. 

Awards & Honours
  • 1st prize. MAHSA Inaugural Research Conference 2015 Cancer: Emperor of All Meladies (Oral Presentation).
  • MyPhD Research Fellowship, granted by Malaysia’s government (Feb 2012-July 2015).
  • Silver medal. Kenaf bio-oil from waste to health and wealth. Malaysia Technology Expo 2011.
  • Silver medal. Kenaf seed oil from supercritical carbon dioxide fluid extraction inhibits the proliferation of WEHI-3B leukemia cells in vivo. Pertandingan Penyelidikan, Rekacipta dan Inovasi (PRPI) UPM 2011.
  • Graduate Research Fellowship (Master), Universiti Putra Malaysia (Dec 2008-Nov 2010).
  • Vice Chancellor Award 2008 (UPM Outstanding Student Award).
  • Tanjong Scholarship Award (Undergraduate) (2005-2008).
 
Professional Affiliations
  • Malaysian Association for Cancer Research (PPM-005-10-18102017) (Lifetime membership L0005)
  • Malaysian Association for Cancer Research (PPM-005-10-18102017) (Honorary Treasurer, 2017-2019)